NAD+ 1500 Dermik 5 vials

NAD+ 1,500 Dermik helps reverse skin aging by maintaining energy metabolism, enhancing DNA repair, activating sirtuins, reducing oxidative stress and inflammation, supporting mitochondrial function, and delaying cellular senescence. Boosting NAD levels through topical applications may help mitigate the signs of aging and promote healthier, more youthful skin.

Indications

Photo Damage including collagen loss, flaccidity, wrinkles, and lack of luminosity.

How to Use

NAD+ 1,500 Dermik can be applied by means of: Virtual Mesotherapy with Electroporation, Iontophoresis (Galvanic Current), Radiofrequency, Cavitation, and Ultrasound MicroNeedling with dermapen or dermarollers Topical Application Post-Peeling Topical Application Post-Microdermabrasion Topical Application with massage.

Each vial contains 1,500 IU of the lyophilized active ingredient that can be reconstituted with 10ml of sterile NaCl 0.9% solution.

Ingredients

Aqua (Water), Nicotinamide Adenine Dinucleotide (NAD+), and Mannitol.

NAD (Nicotinamide Adenine Dinucleotide) plays a critical role in regulating skin aging through several biological processes. As a coenzyme found in all living cells, NAD is essential for energy metabolism and cellular function. Its levels naturally decline with age, and this reduction is associated with various signs of aging. Here’s how NAD regulates skin aging:

Energy Metabolism:

Role in ATP Production: NAD is a crucial component of the cellular energy production process, particularly in the mitochondria where it assists in the production of ATP (adenosine triphosphate). Adequate energy is necessary for skin cells to perform their functions, including repair and regeneration. Reduced NAD levels can impair these processes, leading to signs of aging such as wrinkles and loss of elasticity.

DNA Repair:

Activation of PARPs: NAD is essential for the activation of poly(ADP-ribose) polymerases (PARPs), which are enzymes involved in DNA repair. Skin cells are constantly exposed to DNA-damaging agents like UV radiation. Efficient DNA repair mechanisms help maintain skin integrity and prevent aging-related damage. Reduced NAD impairs this repair process, leading to accumulated DNA damage and accelerated aging.

Sirtuin Activation:

Sirtuins and Longevity: NAD acts as a substrate for sirtuins, a family of enzymes that regulate cellular health and longevity. Sirtuins influence various cellular processes, including inflammation, stress resistance, and DNA repair. By activating sirtuins, NAD promotes skin cell survival and function, thereby mitigating the aging process.

Oxidative Stress Reduction:

Antioxidant Defense: NAD helps in the maintenance of redox balance by participating in reactions that neutralize reactive oxygen species (ROS). High levels of ROS can lead to oxidative stress, damaging cellular components and accelerating skin aging. By supporting antioxidant defenses, NAD helps protect the skin from oxidative damage.

Inflammation Regulation:

Anti-Inflammatory Effects: Chronic inflammation is a key driver of aging. NAD influences inflammatory pathways and helps reduce chronic inflammation. Lower NAD levels are associated with increased inflammation, contributing to aging and related skin conditions.

Mitochondrial Function:

Maintaining Mitochondrial Health: NAD is vital for mitochondrial function and biogenesis. Healthy mitochondria are crucial for energy production and overall cellular health. Dysfunctional mitochondria contribute to aging and skin degeneration. By maintaining mitochondrial function, NAD supports youthful skin.

Senescence Delay:

Preventing Cellular Senescence: Cellular senescence, where cells  stop                               dividing and enter a state of permanent growth arrest, contributes to                                 aging and age-related diseases. NAD helps prevent cellular senescence by                       supporting cellular repair and maintenance mechanisms.