Argireline Dermik

Argireline Dermik are two peptides help improve the appearance of photo aged skin especially when wrinkles and fine expression lines are present.  These peptides work best in the upper 1/3 (third) of the face and crow's feet.

Presentation: 10 ampoules x 2ml (20ml) or 20 ampoules x 2ml (40ml)

Indications

• Wrinkles, Crow's Feet and Fine Expression Lines

How to Use

Argireline Dermik can be applied by means of:

• Virtual Mesotherapy with Electroporation.
• Iontophoresis (Galvanic Current).
• Radiofrequency.
• MicroNeedling with dermapen or dermarollers.
• Topical Application Post-Peeling.
• Topical Application Post-Microdermabrasion.
• Topical Application with massage.

Results can usually be seen after consistent use.

Ingredients

Argireline (Acetyl Hexapeptide-8) and Leuphasyl (Pentapeptide-18)

Argireline, also known as Acetyl Hexapeptide-8, is a synthetic peptide used in skincare products for its anti-aging wrinkle relaxing properties. 

Key Information about Argireline:
1. Mechanism of Action

• Argireline works by inhibiting the release of neurotransmitters that cause facial muscle contractions.
• This combats the appearance of dynamic wrinkles, particularly around the eyes and forehead, by preventing the skin from folding as much during expressions.

2. Benefits

• Improves and softens the aspect of fine lines and wrinkles, especially expression lines.
• Non-invasive alternative
• Improves skin texture and smoothness.
  

3. Usage

• Commonly found in serums, creams, and eye treatments.
• Typically used in concentrations of 5–10% for optimal results.
  

4. Side Effects

• Generally well-tolerated with a low risk of irritation.
• Some people may experience mild redness or tingling, especially with higher concentrations or sensitive skin.

5. Efficacy

• Results can usually be seen with consistent use.
• Works best as a preventative and mild treatment for early signs of aging.
  

6. Common Product Examples

• The Ordinary Argireline Solution 10%
• Matrixyl and Argireline combinations
• Various peptide-based anti-aging serums

 What is Leuphasyl?

INCI Name: Pentapeptide-18

It mimics the natural mechanism of enkephalins, which are neurotransmitters that reduce nerve cell excitability. Often used in combination with Argireline for a synergistic effect in relaxing facial muscles.

💡 How It Works:

• Leuphasyl interferes with the neuronal signaling that triggers muscle contraction.
• By modulating acetylcholine release, it reduces muscle movement, helping to soften dynamic wrinkles (those caused by facial expressions).
  

✅ Benefits
Helps improve and soften the depth of expression wrinkles, particularly:

• Forehead lines
• Crow’s feet
• Frown lines

Boosts the efficacy of other peptides like Argireline when used together.

🧴 Usage and Formulation:

• Found in serums, creams, and eye treatments.
• Commonly used in peptide complexes with Argireline and Matrixyl.
• Typical concentration in skincare: 1–5%.

🛡️ Safety and Side Effects:

• Non-toxic and well-tolerated in most skin types.
• Minimal side effects: some users may notice mild irritation with higher concentrations or if used too frequently.

🔬 Scientific Insight:

• Studies suggest Leuphasyl can improve the signs of wrinkle depth with prolonged use especially when combined with Argireline.
• Works best as part of a long-term skincare routine, not as a quick fix.

🧪 Commonly Found In:

• Anti-aging formulations from brands focused on peptide-based skincare.

Often paired with:

• Argireline (Acetyl Hexapeptide-8)
• Matrixyl (Palmitoyl Pentapeptide-4 or -5)
• Syn-Ake (Dipeptide Diaminobutyroyl Benzylamide Diacetate)

NovaSkin & MediDermik